Boost Your Immune System With Mushrooms

Mushrooms Photo by Jjok

Mushrooms may not be the richest source of the better known micronutrients – your magnesiums, calciums, vitamin Cs, vitamin B12s, vitamin As – but they’re good sources of relatively rare nutrients like selenium, copper, and pantothenic acid. Fresh mushrooms also enjoy sunbathing, synthesize a good amount of vitamin D in response to it that we can utilize and absorb when we eat them. You can even buy some mushrooms from the store, lay them out on a plate in the afternoon sun for a couple hours, and they’ll synthesize vitamin D. Cool, huh?

But the real interesting properties of mushrooms lie in the compounds that don’t appear in FitDay or the USDA nutrient database. Many, perhaps most edible mushrooms contain substances with therapeutic, medicinal, or otherwise pharmacological effects. Let’s look at a few of them:


Shiitakes are denser, heavier, and higher in protein and iron than most other varieties. They’re also more expensive, but they’re probably worth it for the potentially therapeutic compounds:

L-ergothioneine is an antioxidant cytoprotectant, meaning it protects cells from oxidative damage. Some researchers think it might “represent a new vitamin” because it can only be obtained through diet. Shiitakes are by far the best source of L-ergothioneine.

Lentinan is a shiitake polysaccharide with anti-tumor and immune boosting effects. In people with depressed immune systems, lentinan can provide a needed increase.


Don’t be fooled by its near paucity of mainstream nutrients. In animal models of arthritis, the lowly white button mushroom reduces the severity. It also elicits a heightened immune response, but only when co-administered with an immune insult (lipopolysaccharide/endotoxin). Simply feeding a mouse lots of white button mushrooms without giving it a reason to require an immune response has no effect (and rightly so). Also, high consumption of button mushrooms has been inversely linked to ovarian cancer in women.


Criminis are young, nubile portobellos. Portobellos are actually just old, crotchety criminis. And both criminis and portobellos are the same species – agaricus bisporus – as the white button mushroom. So everything mentioned in the last section applies here, too. As for portobellos, they’re famous for “replacing” meat in burgers and sandwiches, but I like portobello mushrooms much better with meat. How about instead of switching out the beef patty for a portobello, we replace the buns with the portobellos?


Ah, man, nothing like a chanterelle sliced and cooked in some broth and butter. It can really make a man overlook the lack of solid research into the mushroom’s health benefits. Eh, some vitamin B12 that may or may not be inactive and preliminary in vitro indications of chemoprevention are good enough for me!


Porcini mushrooms are invaluable when cooking Italian food, so it’s okay that there’s not much solid evidence for miraculous health benefits. They do, however, help hypertensive rats manage their blood pressure and improve the metabolic abnormalities often associated with hypertension.


They appear on tree trunks, require delicate handling to avoid breaking, and may (big “may”) mimic nerve growth factor enough to stimulate the formation of new synapses. Oyster mushrooms also show anti-candida activity and contain a wealth of antioxidant compounds.

Lion’s Mane

It tastes like lobster and could potentially improve your cognition, so I’m going to reiterate. Lion’s Mane usually comes dried and may reverse mild cognitive decline in the elderly, help people with nerve damage regenerate destroyed nerves and regain their ability to walk, and act as a nootropic in healthy people.

As you can see, every mushroom people have looked into seems to be good for us. And there are some commonalities that keep appearing: some interaction with nerve growth factor, cognitive function, immune function; a host of antioxidant compounds. Great in omelets, perfect alongside a steak, and ideal for boosting the immune system.

A few tips:

  • Cook them. Fungal cell walls are made of chitin, the same “fiber” found in insect carapaces. Chitin can be difficult to digest, but heat breaks it down, making the mushroom easier to digest and unlocking the nutrients. A sautéed mushroom also just tastes really, really good.
  • A real simple, foolproof way to cook mushrooms (any mushroom I’ve come across) is to slice them and saute in butter and/or olive oil for about five minutes, or until they begin to soften and darken. Then you add a few dashes of Worcestershire sauce, a few dashes of balsamic vinegar, some red wine, or maybe some good beef or chicken stock. Anything that you can reduce will work. Reduce that down over low heat until the sauce gets syrupy. Sprinkle sea salt and cracked black pepper to taste.
  • I suggest checking out the dried mushroom aisle of an Asian grocery. Those are great to add to soups and stews (no rehydration required), and there are just so many interesting kinds to choose.
  • And go to the local farmer’s market. There’s usually a mushroom guy there with dozens of varieties that you’d never find in a grocery store. He can tell you what they taste like, how to cook them, and what to expect from them because he most likely cultivated them. Make friends with the mushroom guy.
  • Wild edible mushrooms abound, but so do poisonous varieties. To avoid getting sick, contact your local Mycological Society; they’re also everywhere. They’ll set you up with guided shroom-hunting tours with local experts, so you know what to look for and what to avoid. You might also check for a mushroom hunting group near you.
  • If you want to grow your own, I suggest checking out the Shroomery forums. Its members focus on cultivation of psychedelic species, but they’re also very knowledgeable about edible cultivation. There’s also a good board dedicated to mushroom hunting and proper identification where you can provide photos and a description (following a template provided by the regulars) and get expert opinions on whether the mushroom you picked is deadly or delicious.


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