Sucralose is found in thousands of low-calorie foods and beverages worldwide, and in the U.S. has the largest market share for artificial sweeteners and sugar substitutes. It first gained regulatory approval in Canada in 1991, with approval in the U.S. occurring in 1998.
The U.S. approval was based on early studies that suggested the majority of sucralose was not absorbed by the gastrointestinal tract but instead was excreted in the feces. As mentioned, this was also a major part of sucralose’s PR campaign in convincing the U.S. public that this unnatural sweetener is safe.
But as noted by the featured study, “The conclusions of the published data, from both rats and humans that ingested sucralose is excreted unchanged (i.e., not metabolized) appear to be premature.”